Aerobic Fitness in Children and Young Adults with Primary Ciliary Dyskinesia
Astrid Madsen,
Kent Green,
Frederik Buchvald,
Birgitte Hanel and
Kim Gjerum Nielsen
PLOS ONE, 2013, vol. 8, issue 8, 1-8
Abstract:
Background: Although aerobic fitness is regarded as an overall prognostic measure of morbidity and mortality, its evaluation in the chronic progressive sinopulmonary disease primary ciliary dyskinesia (PCD) has been infrequently and inconsistently reported. Here we assessed peak oxygen uptake (VO2peak) in a large well-characterized cohort of PCD patients, and explored whether VO2peak was associated with parameters of pulmonary function, self-reported physical limitations, and physical activity level. Methods: VO2peak, spirometry, diffusing capacity, whole-body plethysmography, and nitrogen multiple breath inert gas washout (N2 MBW) were assessed in a cross-sectional, single-occasion study of clinically stable children and young adults with PCD. We used a questionnaire including self-reported physical limitations in everyday life or in vigorous activities, and estimation of weekly hours of strenuous physical activity. VO2peak in PCD patients was compared with that in matched, healthy control subjects and a national reference. Results: Forty-four PCD patients aged 6–29 years exhibited reduced VO2peak compared to healthy controls (P
Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0071409
DOI: 10.1371/journal.pone.0071409
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