GSTP1 Ile105Val Polymorphism and Prostate Cancer Risk: Evidence from a Meta-Analysis

Bingbing Wei, You Zhou, Zhuoqun Xu, Jun Ruan, Huan Cheng, Ming Zhu, Qiang Hu, Ke Jin, Zhiqiang Yan, Deqi Zhou, Feng Xuan, Hongyi Zhou, Zhirong Wang, Xing Huang and Qiang Wang

PLOS ONE, 2013, vol. 8, issue 8, 1-6

Abstract: Background: Glutathione S-transferase P1 (GSTP1) is thought to be involved in the detoxification of reactive carcinogen metabolites. Numerous epidemiological studies have evaluated the association of GSTP1 Ile105Val polymorphism with the risk of prostate cancer. However, the results remain inconclusive. To derive a more precise estimation, a meta-analysis was performed. Methodology/Principal Findings: A comprehensive search was conducted to identify the eligible studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the relationship. The overall association was not significant (Val/Val vs. Ile/Ile OR = 1.06, 95% CI = 0.90–1.25, P = 0.50; Val/Val vs. Val/Ile+Ile/Ile: OR = 1.07, 95% CI = 0.91–1.25, P = 0.44). In subgroup analyses by ethnicity and prostate cancer grade, the similar results were observed. However, in stratified analysis by clinical stage, we found a significant association with low-stage prostate cancer (Val/Val vs. Ile/Ile: OR = 2.70, 95% CI = 1.73–4.22, P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0071640

DOI: 10.1371/journal.pone.0071640

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