Cancer Mortality in Chinese Chrysotile Asbestos Miners: Exposure-Response Relationships

Xiaorong Wang, Eiji Yano, Sihao Lin, Ignatius T S Yu, Yajia Lan, Lap Ah Tse, Hong Qiu and David C Christiani

PLOS ONE, 2013, vol. 8, issue 8, 1-8

Abstract: Objective: This study was conducted to assess the relationship of mortality from lung cancer and other selected causes to asbestos exposure levels. Methods: A cohort of 1539 male workers from a chrysotile mine in China was followed for 26 years. Data on vital status, occupation and smoking were collected from the mine records and individual contacts. Causes and dates of death were further verified from the local death registry. Individual cumulative fibre exposures (f-yr/ml) were estimated based on converted dust measurements and working years at specific workshops. Standardized mortality ratios (SMRs) for lung cancer, gastrointestinal (GI) cancer, all cancers and nonmalignant respiratory diseases (NMRD) stratified by employment years, estimated cumulative fibre exposures, and smoking, were calculated. Poisson models were fitted to determine exposure-response relationships between estimated fibre exposures and cause-specific mortality, adjusting for age and smoking. Results: SMRs for lung cancer increased with employment years at entry to the study, by 3.5-fold in ≥10 years and 5.3-fold in ≥20 years compared with

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0071899

DOI: 10.1371/journal.pone.0071899

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