Association between 1p11-rs11249433 Polymorphism and Breast Cancer Susceptibility: Evidence from 15 Case-Control Studies

Sheng Wu, Jungang Cai, Hong Wang, Hongwei Zhang and Weige Yang

PLOS ONE, 2013, vol. 8, issue 8, 1-

Abstract: Genome-wide association studies have identified SNP rs11249433 at chromosome 1p11 as a new breast cancer (BC) susceptibility locus in populations of European descent. Since then, the relationship between 1p11- rs11249433 and breast cancer has been reported in various ethnic groups; however, these studies have yielded inconsistent results. To investigate this inconsistency, we performed a meta-analysis of 15 studies involving a total of 90,154 cases and 137,238 controls for 1p11-rs11249433 polymorphism to evaluate its effect on genetic susceptibility for breast cancer. An overall random effects odds ratio of 1.09 (95% CI: 1.06-1.12, P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0072526

DOI: 10.1371/journal.pone.0072526

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