Pentraxin-3 Serum Levels Are Associated with Disease Severity and Mortality in Patients with Systemic Inflammatory Response Syndrome

Simone Bastrup-Birk, Mikkel-Ole Skjoedt, Lea Munthe-Fog, Jens J Strom, Ying Jie Ma and Peter Garred

PLOS ONE, 2013, vol. 8, issue 9, 1-9

Abstract: The long pentraxin-3 (PTX3) is a key component of the humoral arm of the innate immune system. PTX3 is produced locally in response to pro-inflammatory stimuli. To investigate PTX3 levels and its use as a biomarker in patients with systemic inflammation, we developed a solid-phase enzyme-linked immunosorbent assay based on novel anti-PTX3 monoclonal antibodies detecting PTX3 with high sensitivity. The assay was applied on 261 consecutive patients admitted to an intensive care unit prospectively monitored with the systemic inflammatory response syndrome (SIRS). 100 blood donors were included as controls. PTX3 levels were elevated in patients (median = 71.3 ng/ml) compared with the controls (median = 0 ng/ml) (Mann-Whitney, p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0073119

DOI: 10.1371/journal.pone.0073119

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