Prognostic Significance of EDN/RB, HJURP, p60/CAF-1 and PDLI4, Four New Markers in High-Grade Gliomas

Marie de Tayrac, Stephan Saikali, Marc Aubry, Pascale Bellaud, Rachel Boniface, Véronique Quillien and Jean Mosser

PLOS ONE, 2013, vol. 8, issue 9, 1-

Abstract: Background: Recent studies have highlighted the heterogeneity of gliomas and demonstrated that molecular and genetic analysis could help in their classification and in the design of treatment protocols. In a previous study we have identified a 4-gene signature highly correlated with survival of glioma patients. The aim of this study is to confirm and extend these findings by investigating the expression of these genes at the protein level and their association with outcome of patients with high grade gliomas. Methodology/Principal Findings: Immunohistochemical staining for EDN/RB, HJURP, p60/CAF-1 and PDLI4 was studied on archive materials from 96 patients (64 glioblastomas and 32 grade III gliomas). The levels of all four proteins differed significantly between grade III and grade IV tumours. The levels of the EDN/RB, HJURP and p60/CAF-1 proteins were strongly associated with overall survival (p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0073332

DOI: 10.1371/journal.pone.0073332

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