Lack of Association between Hsa-miR-149 rs2292832 Polymorphism and Cancer Risk: A Meta-Analysis of 12 Studies

Lei Xu, Xin Zhou, Man-Tang Qiu, Rong Yin, Ya-Qin Wu and Lin Xu

PLOS ONE, 2013, vol. 8, issue 9, 1-

Abstract: Background: MicroRNAs (miRNAs) participate in various cellular processes such as cell growth, differentiation, cell death and play an important role in a variety of diseases, especially in cancer. Recently, a number of studies have investigated the association between single nucleotide polymorphisms (SNPs) on the hsa-miR-149 rs2292832 and susceptibility to cancer; however, the results remain inconclusive. Methodology/Principal Findings: We carried out a meta-analysis of 12 studies including 5937 cases and 6081 controls from PubMed to assess the association between the hsa-miR-149 rs2292832 and cancer risk by pooled odds ratios (ORs) and 95% confidence intervals (CIs). However, our results showed that genotype distribution of the hsa-miR-149 rs2292832 was not associated with cancer risk in all genetic models. Subgroup analysis by cancer type, ethnicity or study design showed no significant association either. Conclusion: Results of this meta-analysis suggest that the hsa-miR-149 rs2292832 polymorphism is not associated with cancer risk in spite of the potentially protective role of C allele in hepatocellular carcinoma and male gastric cancer.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0073762

DOI: 10.1371/journal.pone.0073762

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