MR Volumetric Study of Piriform-Cortical Amygdala and Orbitofrontal Cortices: The Aging Effect

Jing Shen, Mohammad A Kassir, Jianlin Wu, Qing Zhang, Shiyu Zhou, Stephanie Y Xuan, Qinghang Li, Yongquan Ye and Jiani Hu

PLOS ONE, 2013, vol. 8, issue 9, 1-

Abstract: Introduction: The piriform cortex and cortical amygdala (PCA) and the orbitofrontal cortex (OFC) are considered olfactory-related brain regions. This study aims to elucidate the normal volumes of PCA and OFC of each age groups (20.0-70.0 year old), and whether the volumes of PCA and OFC decline with increasing age and diminishing olfactory function. Methods: One hundred and eleven healthy right-handed participants (54 males, 57 females), age 20.0 to 70.0 years were recruited to join this study after excluding all the major causes of olfactory dysfunction. Volumetric measurements of PCA and OFC were performed using consecutive 1-mm thick coronal slices of high-resolution 3-D MRIs. A validated olfactory function test (Sniffin’ Sticks) assessed olfactory function, which measured odor threshold (THD), odor discrimination (DIS), and odor identification (ID) as well as their sum score (TDI). Results: The volume of OFC decreased with age and significantly correlated with age-related declines in olfactory function. The volume of OFC showed significant age-group differences, particularly after 40 years old (p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0074526

DOI: 10.1371/journal.pone.0074526

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