FASL rs763110 Polymorphism Contributes to Cancer Risk: An Updated Meta-Analysis Involving 43,295 Subjects

Lei Xu, Xin Zhou, Feng Jiang, Man-Tang Qiu, Zhi Zhang, Rong Yin and Lin Xu

PLOS ONE, 2013, vol. 8, issue 9, 1-9

Abstract: Background: Published studies investigating the association between genetic polymorphism -884C/T (rs763110) of the FAS ligand (FASL) promoter and cancer risk reported inconclusive results. To derive a more precise estimation of the relationship, we performed an updated meta-analysis of all eligible studies. Methodology/Principal Findings: We carried out a meta-analysis, including 47 studies with 19,810 cases and 23,485 controls, to confirm a more conclusive association between the FASL rs763110 polymorphism and cancer susceptibility. Overall, significantly reduced cancer risk was associated with the variant -884T when all studies were pooled (TC vs. CC: OR = 0.83, 95%CI = 0.75–0.92; Pheterogeneity

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0074543

DOI: 10.1371/journal.pone.0074543

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