High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers

Olivier Lambotte, Justin Pollara, Faroudy Boufassa, Christiane Moog, Alain Venet, Barton F Haynes, Jean-François Delfraissy, Asier Saez-Cirion and Guido Ferrari

PLOS ONE, 2013, vol. 8, issue 9, 1-5

Abstract: The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0074855

DOI: 10.1371/journal.pone.0074855

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