MGMT Leu84Phe Polymorphism Contributes to Cancer Susceptibility: Evidence from 44 Case-Control Studies

Jun Liu, Renxia Zhang, Fei Chen, Cuicui Yu, Yan Sun, Chuanliang Jia, Lijing Zhang, Taufiq Salahuddin, Xiaodong Li, Juntian Lang and Xicheng Song

PLOS ONE, 2013, vol. 8, issue 9, 1-

Abstract: Background: O6-methylguanine-DNA methyltransferase is one of the few proteins to directly remove alkylating agents in the human DNA direct reversal repair pathway. A large number of case-control studies have been conducted to explore the association between MGMT Leu84Phe polymorphism and cancer risk. However, the results were not consistent. Methods: We carried out a meta-analysis of 44 case-control studies to clarify the association between the Leu84Phe polymorphism and cancer risk. Results: Overall, significant association of the T allele with cancer susceptibility was verified with meta-analysis under a recessive genetic model (P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0075367

DOI: 10.1371/journal.pone.0075367

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