Impact of Over-the-Counter Restrictions on Antibiotic Consumption in Brazil and Mexico

Yared Santa-Ana-Tellez, Aukje K Mantel-Teeuwisse, Anahi Dreser, Hubert G M Leufkens and Veronika J Wirtz

PLOS ONE, 2013, vol. 8, issue 10, 1-6

Abstract: Background: In Latin American countries over-the-counter (OTC) dispensing of antibiotics is common. In 2010, both Mexico and Brazil implemented policies to enforce existing laws of restricting consumption of antibiotics only to patients presenting a prescription. The objective of the present study is therefore to evaluate the impact of OTC restrictions (2010) on antibiotics consumption in Brazil and Mexico. Methods and Findings: Retail quarterly sales data in kilograms of oral and injectable antibiotics between January 2007 and June 2012 for Brazil and Mexico were obtained from IMS Health. The unit of analysis for antibiotics consumption was the defined daily dose per 1,000 inhabitants per day (DDD/TID) according to the WHO ATC classification system. Interrupted time series analysis was conducted using antihypertensives as reference group to account for changes occurring independently of the OTC restrictions directed at antibiotics. To reduce the effect of (a) seasonality and (b) autocorrelation, dummy variables and Prais-Winsten regression were used respectively. Conclusions: Despite different overall usage patterns of antibiotics in Brazil and Mexico, the effect of the OTC restrictions on antibiotics usage was similar. In Brazil the trend of increased usage of antibiotics was tempered after the OTC restrictions; in Mexico the trend of decreased usage was boosted.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0075550

DOI: 10.1371/journal.pone.0075550

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