Variation of Transaminases, HCV-RNA Levels and Th1/Th2 Cytokine Production during the Post-Partum Period in Pregnant Women with Chronic Hepatitis C

Ángeles Ruiz-Extremera, José Antonio Muñoz-Gámez, Ana Abril-Molina, María Angustias Salmerón-Ruiz, Paloma Muñoz- de-Rueda, Esther José Pavón-Castillero, Rosa Quiles-Pérez, Ángel Carazo, Ana Gila, Sergio Manuel Jimenez-Ruiz, Jorge Casado, Ana Belén Martín, Laura Sanjuán-Núñez, Esther Ocete-Hita, Julián López Viota, Josefa León and Javier Salmerón

PLOS ONE, 2013, vol. 8, issue 10, 1-9

Abstract: This study analyses the evolution of liver disease in women with chronic hepatitis C during the third trimester of pregnancy and the post-partum period, as a natural model of immune modulation and reconstitution. Of the 122 mothers recruited to this study, 89 were HCV-RNA+ve/HIV-ve and 33 were HCV-RNA-ve/HIV-ve/HCVantibody+ve and all were tested during the third trimester of pregnancy, at delivery and post-delivery. The HCV-RNA+ve mothers were categorized as either Type-A (66%), with an increase in ALT levels in the post-partum period (>40 U/L; P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0075613

DOI: 10.1371/journal.pone.0075613

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