Tumor Secretion of CCL22 Activates Intratumoral Treg Infiltration and Is Independent Prognostic Predictor of Breast Cancer

Ya-Qing Li, Fang-Fang Liu, Xin-Min Zhang, Xiao-Jing Guo, Mei-Jing Ren and Li Fu

PLOS ONE, 2013, vol. 8, issue 10, 1-

Abstract: It has been reported that dense intratumoral infiltration of Foxp3 +Tregs (Tregs) was an independent factor for poor prognosis of breast cancer (BC) patients. However, the cytokines activating the Treg infiltration are not known. This study was undertaken to evaluate the role of CCL22 and TGF-β1 in this cascade and their prognostic significance for BC patients. 417 cases of invasive breast cancer were selected from the prior study cohort and the expressions of CCL22 and TGF-β1 were assessed by immunohistochemistry. It was identified that tumor secretion of CCL22 was positively correlated with the intratumoral Treg infiltration (P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0076379

DOI: 10.1371/journal.pone.0076379

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