Genome-Wide Association Study of Breast Cancer in the Japanese Population

Siew-Kee Low, Atsushi Takahashi, Kyota Ashikawa, Johji Inazawa, Yoshio Miki, Michiaki Kubo, Yusuke Nakamura and Toyomasa Katagiri

PLOS ONE, 2013, vol. 8, issue 10, 1-8

Abstract: Breast cancer is the most common malignancy among women in worldwide including Japan. Several studies have identified common genetic variants to be associated with the risk of breast cancer. Due to the complex linkage disequilibrium structure and various environmental exposures in different populations, it is essential to identify variants associated with breast cancer in each population, which subsequently facilitate the better understanding of mammary carcinogenesis. In this study, we conducted a genome-wide association study (GWAS) as well as whole-genome imputation with 2,642 cases and 2,099 unaffected female controls. We further examined 13 suggestive loci (P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0076463

DOI: 10.1371/journal.pone.0076463

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