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Fecal Microbiota and Metabolome of Children with Autism and Pervasive Developmental Disorder Not Otherwise Specified

Maria De Angelis, Maria Piccolo, Lucia Vannini, Sonya Siragusa, Andrea De Giacomo, Diana Isabella Serrazzanetti, Fernanda Cristofori, Maria Elisabetta Guerzoni, Marco Gobbetti and Ruggiero Francavilla

PLOS ONE, 2013, vol. 8, issue 10, 1-

Abstract: This study aimed at investigating the fecal microbiota and metabolome of children with Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and autism (AD) in comparison to healthy children (HC). Bacterial tag-encoded FLX-titanium amplicon pyrosequencing (bTEFAP) of the 16S rDNA and 16S rRNA analyses were carried out to determine total bacteria (16S rDNA) and metabolically active bacteria (16S rRNA), respectively. The main bacterial phyla (Firmicutes, Bacteroidetes, Fusobacteria and Verrucomicrobia) significantly (P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0076993

DOI: 10.1371/journal.pone.0076993

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