Cytokine Profiles at Birth Predict Malaria Severity during Infancy

Edward Kabyemela, Bronner P Gonçalves, D Rebecca Prevots, Robert Morrison, Whitney Harrington, Moses Gwamaka, Jonathan D Kurtis, Michal Fried and Patrick E Duffy

PLOS ONE, 2013, vol. 8, issue 10, 1-

Abstract: Background: Severe malaria risk varies between individuals, and most of this variation remains unexplained. Here, we examined the hypothesis that cytokine profiles at birth reflect inter-individual differences that persist and influence malaria parasite density and disease severity throughout early childhood. Methods and Findings: Cytokine levels (TNF-α, IFN-γ, IL-1β, IL-4, IL-5, IL-6 and IL-10) were measured at birth (cord blood; N=783) and during subsequent routine follow-up visits (peripheral blood) for children enrolled between 2002 and 2006 into a birth cohort in Muheza, Tanzania. Children underwent blood smear and clinical assessments every 2-4 weeks, and at the time of any illness. Cord blood levels of all cytokines were positively correlated with each other (Spearman’s rank correlation). Cord levels of IL-1β and TNF-α (but not other cytokines) correlated with levels of the same cytokine measured at routine visits during early life (P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0077214

DOI: 10.1371/journal.pone.0077214

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