Can K-ras Gene Mutation Be Utilized as Prognostic Biomarker for Colorectal Cancer Patients Receiving Chemotherapy? A Meta-Analysis and Systematic Review

Yuan-Yi Rui, Dan Zhang, Zong-Guang Zhou, Cun Wang, Lie Yang, Yong-Yang Yu and Hai-Ning Chen

PLOS ONE, 2013, vol. 8, issue 10, 1-

Abstract: Introduction: K-ras gene mutations were common in colorectal patients, but their relationship with prognosis was unclear. Objective: Verify prognostic differences between patient with and without mutant K-ras genes by reviewing the published evidence. Method: Systematic reviews and data bases were searched for cohort/case-control studies of prognosis of colorectal cancer patients with detected K-ras mutations versus those without mutant K-ras genes, both of whom received chemotherapy. Number of patients, regimens of chemotherapy, and short-term or long-term survival rate (disease-free or overall) were extracted. Quality of studies was also evaluated. Principal Findings: 7 studies of comparisons with a control group were identified. No association between K-ras gene status with neither short-term disease free-survival (OR=1.01, 95% CI, 0.73-1.38, P=0.97) nor overall survival (OR=1.06, 95% CI, 0.82-1.36, P=0.66) in CRC patients who received chemotherapy was indicated. Comparison of long-term survival between two groups also indicated no significant difference after heterogeneity was eliminated (OR=1.09, 95% CI, 0.85-1.40, P=0.49). Conclusions: K-ras gene mutations may not be a prognostic index for colorectal cancer patients who received chemotherapy.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0077901

DOI: 10.1371/journal.pone.0077901

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