Association between Adiponectin Concentrations and Cardiovascular Disease in Diabetic Patients: A Systematic Review and Meta-Analysis

Zhenjie Wu, Yunjiu Cheng, Lynn Htet Htet Aung and Bixun Li

PLOS ONE, 2013, vol. 8, issue 11, 1-6

Abstract: Background: This systematic review and meta-analysis of prospective studies evaluates the association between adiponectin concentrations and risk of cardiovascular disease (CVD) in individuals with diabetes mellitus (DM). Methods: PubMed and Embase were searched for prospective studies on the association of adiponectin concentrations and risk of CVD up to June 2013. Random-effect model was selected to pool the relative risk (RR) and 95% CI. Results: Five prospective cohort studies and one nested case-control studies met the included criterion. The estimated summary RR and 95% CI of five prospective cohort studies for type 2 diabetes comparing top vs low tertile of adiponectin concentrations was 0.99 (95% CI: 0.67–1.45), with significant heterogeneity between studies (p = 0.037, I2 = 60.9%). This heterogeneity was explained by one study conducted in Korean. Conclusions: This study represents the first meta-analysis between adiponectin levels and CVD in diabetic patients and indicated no association was found. This result should be verified further by large sample size, long duration of follow-up, and well-designed prospective clinical trials.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0078485

DOI: 10.1371/journal.pone.0078485

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