Determinants of Brushite Stone Formation: A Case-Control Study

Roswitha Siener, Linda Netzer and Albrecht Hesse

PLOS ONE, 2013, vol. 8, issue 11, 1-6

Abstract: Purpose: The occurrence of brushite stones has increased during recent years. However, the pathogenic factors driving the development of brushite stones remain unclear. Methods: Twenty-eight brushite stone formers and 28 age-, sex- and BMI-matched healthy individuals were enrolled in this case-control study. Anthropometric, clinical, 24 h urinary parameters and dietary intake from 7-day weighed food records were assessed. Results: Pure brushite stones were present in 46% of patients, while calcium oxalate was the major secondary stone component. Urinary pH and oxalate excretion were significantly higher, whereas urinary citrate was lower in patients as compared to healthy controls. Despite lower dietary intake, urinary calcium excretion was significantly higher in brushite stone patients. Binary logistic regression analysis revealed pH>6.50 (OR 7.296; p = 0.035), calcium>6.40 mmol/24 h (OR 25.213; p = 0.001) and citrate excretion

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0078996

DOI: 10.1371/journal.pone.0078996

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