Periodontal Disease and Risk of Head and Neck Cancer: A Meta-Analysis of Observational Studies

Xian-Tao Zeng, Ai-Ping Deng, Cheng Li, Ling-Yun Xia, Yu-Ming Niu and Wei-Dong Leng

PLOS ONE, 2013, vol. 8, issue 10, 1-

Abstract: Background: Many epidemiological studies have found a positive association of periodontal disease (PD) with risk of head and neck cancer (HNC), but the findings are varied or even contradictory. In this work, we performed a meta-analysis to ascertain the relationship between PD and HNC risk. Methods: We searched the PubMed, Embase, and Cochrane Library databases for relevant observational studies on the association between PD and HNC risk published up to March 23, 2013. Data from the included studies were extracted and analyzed independently by two authors. Meta-analysis was performed using RevMan 5.2 software. Results: We obtained seven observational studies involving two cohort and six case-control studies. Random-effects meta-analysis indicated a significant association between PD and HNC risk (odds ratio = 2.63, 95% confidence interval = 1.1.68 - 4.14; p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0079017

DOI: 10.1371/journal.pone.0079017

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