c-Met as a Prognostic Marker in Gastric Cancer: A Systematic Review and Meta-Analysis

Shan Yu, Yiyi Yu, Naiqing Zhao, Jianlan Cui, Wei Li and Tianshu Liu

PLOS ONE, 2013, vol. 8, issue 11, 1-

Abstract: Background: c-Met has been recognized as an important therapeutic target in gastric cancer, but the prognostic property of the c-Met status is still unclear. We aimed to characterize the prognostic effect of c-Met by systematic review and meta-analysis. Methods: We identified 15 studies assessing survival in gastric cancer by c-Met status. Effect measure of interest was hazard ratio (HR) for survival. Meta-regression was performed to estimate the relationship between HR and disease stage. Random-effects meta-analyses were used to account for heterogeneity. Results: 15 eligible studies provided outcome data stratified by c-Met status in 2210 patients. Meta-analysis of the HRs indicated a significantly poorer Os in patients with high c-Met expression (average HR=2.112, 95%CI: 1.622–2.748). Subgroup analysis showed the prognostic effect of c-Met was identical in protein-level and gene-level based methodology. The same effect was also seen in Asian and Western ethnicity subgroup analysis. Meta-regression showed HR was not associated with disease stage. Conclusions: Patients with tumors that harbor high c-Met expression are more likely to have a worse Os, with this prognostic effect independent of disease stage. c-Met status should be evaluated in clinical prognosis.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0079137

DOI: 10.1371/journal.pone.0079137

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