B-Type Natriuretic Peptide and Prognosis of End-Stage Renal Disease: A Meta-Analysis

Yun-Jiu Cheng, Feng-Juan Yao, Li-Juan Liu, Kai Tang, Xiao-Xiong Lin, Wei-Jie Li, Jing Zhang and Su-Hua Wu

PLOS ONE, 2013, vol. 8, issue 11, 1-9

Abstract: Background: The prognostic importance of B-type natriuretic peptide (BNP) or N-terminal pro BNP (NT-proBNP) in patients with end-stage renal disease (ESRD) remains controversial. Methodology/Principal Findings: We conducted an unrestricted search from the MEDLINE and EMBASE in all languages that were published between 1966 and Augest2013. Twenty-seven long-term prospective studies met our inclusion criterias. From the pooled analysis, elevated BNP/NT-proBNP was significantly associated with increased all cause mortality [odds ratio (OR), 3.85; 95% CI, 3.11 to 4.75], cardiovascular mortality (OR, 4.05; 95% CI, 2.53 to 6.84), and cardiovascular events (OR, 7.02; 95% CI, 2.21 to 22.33). The funnel plot showed no evidence of publication bias. The corresponding pooled positive and negative likelihood ratio for prediction of all cause mortality were 1.86 (95% CI, 1.66 to 2.08) and 0.48 (95% CI, 0.42 to 0.55), respectively. Conclusions/Significance: BNP/NT-proBNP is a promising prognostic tool to risk-stratify the patients with ESRD. Further investigations are warranted to elucidate the specific pathogenic mechanisms and the impact of other potential prognostic factors.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0079302

DOI: 10.1371/journal.pone.0079302

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