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Long-Term Unemployment Is Associated with Short Telomeres in 31-Year-Old Men: An Observational Study in the Northern Finland Birth Cohort 1966

Leena Ala-Mursula, Jessica L Buxton, Ellen Ek, Markku Koiranen, Anja Taanila, Alexandra I F Blakemore and Marjo-Riitta Järvelin

PLOS ONE, 2013, vol. 8, issue 11, 1-8

Abstract: Objective: Life stress resulting from early-life experiences and domestic stress is linked with shorter leukocyte telomere length (LTL), but evidence on employment-related stress is scarce. We explored whether unemployment in early adulthood is associated with shorter LTL, a potential biomarker of premature aging. Methods: We used data from 5620 men and women belonging to the Northern Finland Birth Cohort 1966. Individually registered unemployment days in 1995–97 were compared with data on biological, behavioral and socioeconomic health predictors and existing medical conditions obtained by surveys and clinical examinations at follow-up in 1997–98. Mean LTL at follow-up was measured by multiplex quantitative real-time PCR. We calculated odds ratios and their 95% confidence intervals (CI) of belonging to the sex-stratified shortest decile of standardized relative mean LTL according to the categories of: 0,

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0080094

DOI: 10.1371/journal.pone.0080094

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