Autophagic Protein Beclin 1 Serves as an Independent Positive Prognostic Biomarker for Non-Small Cell Lung Cancer

Weihua Zhou, Caifeng Yue, Jinyun Deng, Ronghuan Hu, Jie Xu, Long Feng, Qiongyu Lan, Wenfeng Zhang, Dexiang Ji, Jianbing Wu, Quentin Liu and Anwen Liu

PLOS ONE, 2013, vol. 8, issue 11, 1-

Abstract: Beclin 1, a key regulator of autophagy, has been found to be aberrantly expressed in a variety of human malignancies. Herein, we employed immunohistochemistry (IHC) to detect the protein expression of Beclin 1 in non-small cell lung cancer (NSCLC) and paired normal adjacent lung tissues, and analyzed its clinicopathological/prognostic significance in NSCLC. Receiver operating characteristic (ROC) curve analysis was utilized to determine a cutoff point (>2 VS. ≤2) for Beclin 1 expression in a training set (n = 105). For validation, the ROC-derived cutoff value was subjected to analysis of the association of Beclin 1 with patients’ clinical characteristics and outcome in a testing set (n = 111) and the overall patient cohort (n = 216). Our data showed that Beclin 1 was significantly lower in NSCLC tissues compared with the adjacent normal tissues, negatively associating with tumor recurrence rate (65.8% VS 32.3%; p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0080338

DOI: 10.1371/journal.pone.0080338

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