HIF-1α 1772 C/T and 1790 G/A Polymorphisms Are Significantly Associated with Higher Cancer Risk: An Updated Meta-Analysis from 34 Case-Control Studies

Xi Yang, Hong-Cheng Zhu, Chi Zhang, Qin Qin, Jia Liu, Li-Ping Xu, Lian-Jun Zhao, Qu Zhang, Jing Cai, Jian-Xin Ma, Hong-Yan Cheng and Xin-Chen Sun

PLOS ONE, 2013, vol. 8, issue 11, 1-

Abstract: Background: HIF-1 activates various genes in cancer progression and metastasis. HIF-1α 1772 C/T and 1790 G/A polymorphisms are reportedly associated with cancer risk; however, the results are inconclusive. Methodology/Principal Findings: A meta-analysis of 34 studies that involved 7522 cases and 9847 controls for 1772 C/T and 24 studies that involved 4884 cases and 8154 controls for 1790 G/A was conducted to identify the association of C/T and G/A polymorphisms with cancer risk. Odds ratio (OR) and 95% confidence intervals (95% CI) were used to assess the strength of association. Conclusions: HIF-1α 1772 C/T and 1790 G/A polymorphisms are significantly associated with higher cancer risk.

Date: 2013
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080396 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 80396&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0080396

DOI: 10.1371/journal.pone.0080396

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().