Causes and Outcomes of Acute Liver Failure in China

Pan Zhao, Chunya Wang, Weiwei Liu, Gang Chen, Xinying Liu, Xi Wang, Bao Wang, Liming Yu, Yanrong Sun, Xiaoming Liang, Haozhen Yang and Fei Zhang

PLOS ONE, 2013, vol. 8, issue 11, 1-

Abstract: Objectives: No extensive investigation has been performed and thus no representative data are available regarding acute liver failure (ALF) in China. This study aims to investigate the causes and outcomes of ALF in China and establish a prognostic model. Methods: Patients diagnosed as ALF in seven hospitals in different areas of China from January 2007 to December 2012 were retrospectively selected. Results: Of the 177 patients included in this study, 112 (63.28%) eventually died. The common causes of ALF were drug toxicity (43.50%), indeterminate etiology (29.38%) and acute viral hepatitis (11.30%). Additionally, traditional Chinese herbs predominated in the causes of drug-induced ALF (30/77). No patients in this study received liver transplantation. In the established model for predicting death in ALF, four variables were finally selected out, including age (P=0.01), the entry hepatic encephalopathy grade (P=0.04), international normalized ratio (P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0080991

DOI: 10.1371/journal.pone.0080991

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