Serum S100B, Lactate Dehydrogenase and Brain Metastasis Are Prognostic Factors in Patients with Distant Melanoma Metastasis and Systemic Therapy

Benjamin Weide, Sabina Richter, Petra Büttner, Ulrike Leiter, Andrea Forschner, Jürgen Bauer, Laura Held, Thomas Kurt Eigentler, Friedegund Meier and Claus Garbe

PLOS ONE, 2013, vol. 8, issue 11, 1-7

Abstract: Background: Prognostic factors of melanoma with distant metastasis and systemic treatment are only poorly established. This study aimed to analyse the impact of S100B, lactate dehydrogenase (LDH) and the type of treatment on survival in advanced patients receiving systemic treatment. Patients and Methods: We analysed overall survival of 499 patients from the university department of dermatology in Tuebingen, Germany, with unresectable melanoma at the time point of initiation of first-line systemic therapy. Only patients who started treatment between the years 2000 and 2010 were included. Disease-specific survival was calculated by bivariate Kaplan Meier survival probabilities and multivariate Cox hazard regression analysis. Results: In univariate analysis LDH, S100B, the site of distant metastasis (soft tissue vs. lung vs. other visceral), the presence of brain metastases and the type of treatment (monochemotherapy, polychemotherapy, immunotherapy or biochemotherapy) were associated with overall survival (all p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0081624

DOI: 10.1371/journal.pone.0081624

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