Apolipoprotein E Gene Variants on the Risk of End Stage Renal Disease

Cheng Xue, Wei Nie, Dan Tang, Lujiang Yi and Changlin Mei

PLOS ONE, 2013, vol. 8, issue 12, 1-

Abstract: Objective: End-stage renal disease (ESRD) is a severe health concern over the world. Associations between apolipoprotein E (apoE) gene polymorphisms and the risk of ESRD remained inconclusive. This study aimed to investigate the association between apoE gene polymorphisms and ESRD susceptibility. Methods: Databases including PubMed, Embase, Web of Science and the Cochrane Library were searched to find relevant studies. Meta-analysis method was used synthesize the eligible studies. Results: Sixteen pertinent case-control studies which included 3510 cases and 13924 controls were analyzed. A significant association was found between ε2 allele and the ESRD risk (odds ratio (OR) = 1.30, 95% confidence interval (CI) 1.15–1.46, P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0083367

DOI: 10.1371/journal.pone.0083367

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