A Linear Combination of Pharmacophore Hypotheses as a New Tool in Search of New Active Compounds – An Application for 5-HT1A Receptor Ligands

Dawid Warszycki, Stefan Mordalski, Kurt Kristiansen, Rafał Kafel, Ingebrigt Sylte, Zdzisław Chilmonczyk and Andrzej J Bojarski

PLOS ONE, 2013, vol. 8, issue 12, 1-

Abstract: This study explores a new approach to pharmacophore screening involving the use of an optimized linear combination of models instead of a single hypothesis. The implementation and evaluation of the developed methodology are performed for a complete known chemical space of 5-HT1AR ligands (3616 active compounds with Ki

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0084510

DOI: 10.1371/journal.pone.0084510

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