Structural and Functional Small Fiber Abnormalities in the Neuropathic Postural Tachycardia Syndrome

Christopher H Gibbons, Istvan Bonyhay, Adam Benson, Ningshan Wang and Roy Freeman

PLOS ONE, 2013, vol. 8, issue 12, 1-

Abstract: Objective: To define the neuropathology, clinical phenotype, autonomic physiology and differentiating features in individuals with neuropathic and non-neuropathic postural tachycardia syndrome (POTS). Methods: Twenty-four subjects with POTS and 10 healthy control subjects had skin biopsy analysis of intra-epidermal nerve fiber density (IENFD), quantitative sensory testing (QST) and autonomic testing. Subjects completed quality of life, fatigue and disability questionnaires. Subjects were divided into neuropathic and non-neuropathic POTS, defined by abnormal IENFD and abnormal small fiber and sudomotor function. Results: Nine of 24 subjects had neuropathic POTS and had significantly lower resting and tilted heart rates; reduced parasympathetic function; and lower phase 4 valsalva maneuver overshoot compared with those with non-neuropathic POTS (P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0084716

DOI: 10.1371/journal.pone.0084716

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