Decreased Expression of PTPN12 Correlates with Tumor Recurrence and Poor Survival of Patients with Hepatocellular Carcinoma

Rong-Zhen Luo, Pei-Qiang Cai, Mei Li, Jia Fu, Zhi-Yi Zhang, Jie-Wei Chen, Yun Cao, Jing-Ping Yun, Dan Xie and Mu-Yan Cai

PLOS ONE, 2014, vol. 9, issue 1, 1-8

Abstract: Background: Protein tyrosine phosphatase non-receptor type 12 (PTPN12), has been identified as a potent tumor suppressor in human cancers and a critical regulator of cell adhesion and migration. However, the PTPN12 expression and its prognostic significance in HCC have not been well elucidated. Methodology/Principal Findings: In this study, tissue microarray-based immunohistochemistry (IHC) was investigated in an HCC cohort with adjacent liver tissues as controls. The resulting data were analyzed using receiver operating characteristic curves, Spearman's rank correlation, Kaplan-Meier plots and Cox proportional hazards regression modeling. Our results showed that decreased expression of PTPN12 was more frequently observed in HCC tissues compared to the adjacent non-tumorous liver tissues. Further correlation analyses indicated that the decreased PTPN12 expression was closely correlated with tumor recurrence (P = 0.015). Univariate analysis showed a significant association between decreased expression of PTPN12 and adverse cancer-specific survival and recurrence-free survival (P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0085592

DOI: 10.1371/journal.pone.0085592

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