Survival According to BRAF-V600 Tumor Mutations – An Analysis of 437 Patients with Primary Melanoma

Diana Meckbach, Jürgen Bauer, Annette Pflugfelder, Friedegund Meier, Christian Busch, Thomas K Eigentler, David Capper, Andreas von Deimling, Michel Mittelbronn, Sven Perner, Kristian Ikenberg, Markus Hantschke, Petra Büttner, Claus Garbe and Benjamin Weide

PLOS ONE, 2014, vol. 9, issue 1, 1-10

Abstract: The prognostic impact of BRAF-V600 tumor mutations in stage I/II melanoma patients has not yet been analyzed in detail. We investigated primary tumors of 437 patients diagnosed between 1989 and 2006 by Sanger sequencing. Mutations were detected in 38.7% of patients and were associated with age, histological subtype as well as mitotic rate. The mutational rate was 36.7% in patients with disease-free course and 51.7% in those with subsequent distant metastasis (p = 0.031). No difference in overall survival (p = 0.119) but a trend for worse distant-metastasis-free survival (p = 0.061) was observed in BRAF mutant compared to BRAF wild-type patients. Independent prognostic factors for overall survival were tumor thickness, mitotic rate and ulceration. An interesting significant prognostic impact was observed in patients with tumor thickness of 1 mm or less, with the mutation present in 6 of 7 patients dying from melanoma. In conclusion, no significant survival differences were found according to BRAF-V600 tumor mutations in patients with primary melanoma but an increasing impact of the mutational status was observed in the subgroup of patients with tumor thickness of 1 mm or less. A potential role of the mutational status as a prognostic factor especially in this subgroup needs to be investigated in larger studies.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0086194

DOI: 10.1371/journal.pone.0086194

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