Comparable Long-Term Efficacy of Lopinavir/Ritonavir and Similar Drug-Resistance Profiles in Different HIV-1 Subtypes

Zehava Grossman, Jonathan M Schapiro, Itzchak Levy, Daniel Elbirt, Michal Chowers, Klaris Riesenberg, Karen Olstein-Pops, Eduardo Shahar, Valery Istomin, Ilan Asher, Bat-Sheva Gottessman, Yonat Shemer, Hila Elinav, Gamal Hassoun, Shira Rosenberg, Diana Averbuch, Keren Machleb-Guri, Zipi Kra-Oz, Sara Radian-Sade, Hagit Rudich, Daniela Ram, Shlomo Maayan, Nancy Agmon-Levin and Zev Sthoeger

PLOS ONE, 2014, vol. 9, issue 1, 1-14

Abstract: Background: Analysis of potentially different impact of Lopinavir/Ritonavir (LPV/r) on non-B subtypes is confounded by dissimilarities in the conditions existing in different countries. We retrospectively compared its impact on populations infected with subtypes B and C in Israel, where patients infected with different subtypes receive the same treatment. Methods: Clinical and demographic data were reported by physicians. Resistance was tested after treatment failure. Statistical analyses were conducted using SPSS. Results: 607 LPV/r treated patients (365 male) were included. 139 had HIV subtype B, 391 C, and 77 other subtypes. At study end 429 (71%) were receiving LPV/r. No significant differences in PI treatment history and in median viral-load (VL) at treatment initiation and termination existed between subtypes. MSM discontinued LPV/r more often than others even when the virologic outcome was good (p = 0.001). VL was below detection level in 81% of patients for whom LPV/r was first PI and in 67% when it was second (P = 0.001). Median VL decrease from baseline was 1.9±0.1 logs and was not significantly associated with subtype. Median CD4 increase was: 162 and 92cells/µl, respectively, for patients receiving LPV/r as first and second PI (P = 0.001), and 175 and 98, respectively, for subtypes B and C (P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0086239

DOI: 10.1371/journal.pone.0086239

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