Interruption and Non-Adherence to Long-Term Adjuvant Hormone Therapy Is Associated with Adverse Survival Outcome of Breast Cancer Women - An Asian Population-Based Study

Kun-Pin Hsieh, Li-Chia Chen, Kwok-Leung Cheung, Chao-Sung Chang and Yi-Hsin Yang

PLOS ONE, 2014, vol. 9, issue 2, 1-9

Abstract: This study aimed to evaluate the survival rate of women with breast cancer (BC) comparing persistence versus interruption and adherence versus non-adherence to adjuvant hormonal therapy (HT) in Asian population. Newly-diagnosed BC women from 2003 to 2010 were retrospectively identified from the Taiwan National Health Insurance Research Database. HT prescriptions were extracted to define treatment interruption and medication possession ratio. Their impacts on mortality were estimated by Cox regression with time dependent covariates. Interruption (HR: 1.32; 95% CI: 1.20, 1.46; P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0087027

DOI: 10.1371/journal.pone.0087027

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