The Effects of Intracranial Pressure Monitoring in Patients with Traumatic Brain Injury

Shao-Hua Su, Fei Wang, Jian Hai, Ning-Tao Liu, Fei Yu, Yi-Fang Wu and You-Hou Zhu

PLOS ONE, 2014, vol. 9, issue 2, 1-13

Abstract: Background: Although international guideline recommended routine intracranial pressure (ICP) monitoring for patients with severe traumatic brain injury(TBI), there were conflicting outcomes attributable to ICP monitoring according to the published studies. Hence, we conducted a meta-analysis to evaluate the efficacy and safety of ICP monitoring in patients with TBI. Methods: Based on previous reviews, PubMed and two Chinese databases (Wangfang and VIP) were further searched to identify eligible studies. The primary outcome was mortality. Secondary outcomes included unfavourable outcome, adverse events, length of ICU stay and length of hospital stay. Weighted mean difference (WMD), odds ratio (OR) and 95% confidence intervals (CIs) were calculated and pooled using fixed-effects or random-effects model. Results: two randomized controlled trials (RCTs) and seven cohort studies involving 11,038 patients met the inclusion criteria. ICP monitoring was not associated with a significant reduction in mortality (OR, 1.16; 95% CI, 0.87–1.54), with substantial heterogeneity (I2 = 80%, P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0087432

DOI: 10.1371/journal.pone.0087432

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