N-acetyltransferase 2 Polymorphisms and Risk of Esophageal Cancer in a Chinese Population

Liming Wang, Weifeng Tang, Suocheng Chen, Yangyong Sun, Yu Fan, Yijun Shi, Jingfeng Zhu, Xu Wang, Liang Zheng, Aizhong Shao, Guowen Ding, Chao Liu, Ruiping Liu, Jun Yin and Haiyong Gu

PLOS ONE, 2014, vol. 9, issue 2, 1-7

Abstract: Esophageal cancer was the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death in China in 2009. Genetic factors might play an important role in the carcinogenesis of esophageal squamous cell carcinoma (ESCC). We conducted a hospital-based case-control study to evaluate ten NAT2 tagging single nucleotide polymorphisms (SNPs) on the risk of ESCC. Six hundred and twenty-nine ESCC cases and 686 controls were recruited. Their genotypes were determined using the ligation detection reaction method. In the single locus analyses, there was a borderline statistically significant difference in genotype frequencies of NAT2 rs1565684 T>C SNP between the cases and the controls (p = 0.057). The NAT2 rs1565684 CC genotype was associated with a borderline significantly increased risk for ESCC (CC vs. TT: adjusted OR = 1.77, 95% CI = 0.97–3.21, p = 0.063 and CC vs. TT/TC: adjusted OR = 1.68, 95% CI = 0.93–3.04, p = 0.085). The association was evident among older patients and patients who never drunk. After the Bonferroni correction, in all comparison models, NAT2 rs1565684 T>C SNP was not associated with ESCC risk (p>0.05). For the other nine NAT2 SNPs, after Bonferroni correction, in all comparison models, the nine SNPs were also not associated with ESCC risk (p>0.05). Thus, nine NAT2 tagging SNPs were not associated with risk of ESCC. NAT2 rs1565684 T>C SNP might play a slight role in ESCC etiology. Additional, larger studies and tissue-specific biological characterization are required to confirm the current findings.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0087783

DOI: 10.1371/journal.pone.0087783

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