Risk of Depressive Disorder following Non-Alcoholic Cirrhosis: A Nationwide Population-Based Study

Chin-Lin Perng, Cheng-Che Shen, Li-Yu Hu, Chiu-Mei Yeh, Mu-Hong Chen, Chia-Fen Tsai, Huey-Ling Chiang, Yi-Ping Hung, Vincent Yi-Fong Su, Yu-Wen Hu, Tung-Ping Su, Pan-Ming Chen, Jeng-Hsiu Hung, Chia-Jen Liu and Min-Wei Huang

PLOS ONE, 2014, vol. 9, issue 2, 1-6

Abstract: Background & Aims: To evaluate the risk of depressive disorders among non-alcoholic patients by using the Taiwan National Health Insurance Research Database (NHIRD). Methods: We conducted a retrospective study of a matched cohort of 52 725 participants (10 545 non-alcoholic cirrhotic patients and 42 180 control patients) who were selected from the NHIRD. Patients were observed for a maximum of 11 years to determine the rates of newly onset depressive disorders, and Cox regression was used to identify the risk factors associated with depressive disorders in cirrhotic patients. Results: During the 11-year follow-up period, 395 (3.75%) non-alcoholic cirrhotic patients and 1 183 (2.80%) control patients were diagnosed with depressive disorders. The incidence risk ratio of depressive disorders between non-alcoholic cirrhotic patients and control patients was 1.76 (95% CI, 1.57–1.98, P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0088721

DOI: 10.1371/journal.pone.0088721

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