Association of Fas -1377 G/A Polymorphism with Susceptibility to Cancer

Peiliang Geng, Jianjun Li, Juanjuan Ou, Ganfeng Xie, Ning Wang, Lisha Xiang, Rina Sa, Chen Liu, Hongtao Li and Houjie Liang

PLOS ONE, 2014, vol. 9, issue 2, 1-8

Abstract: Background: The relationship between Fas -1377 G/A polymorphism and cancer susceptibility has been implicated in accumulating data. However, the data presented inconsistent results. This study was devised to investigate the association of Fas -1377 G/A polymorphism and cancer susceptibility in a large number of participants. Methods: The databases of PubMed, Embase, and Web of Science were searched and a total of 27 case-control studies including 13,355 cases and 16,078 controls were included in this meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the fixed-effects model. Statistical analyses were performed by using Stata software. Results: The results suggested that Fas -1377 G/A polymorphism was overall associated with cancer susceptibility (additive model: OR, 1.16, 95%CI = 1.06–1.27, Pheterogeneity = 0.381; recessive model: OR, 1.19, 95%CI = 1.10–1.29, Pheterogeneity = 0.137). In the subgroup analysis by cancer type, significantly increased risk was observed in breast cancer (additive model: OR, 1.24, 95%CI = 1.04–1.58, Pheterogeneity = 0.614; recessive model: OR, 1.24, 95%CI = 1.02–1.51, Pheterogeneity = 0.349) and lung cancer (recessive model: OR, 1.25, 95%CI = 1.04–1.49, Pheterogeneity = 0.090). Similarly, elevated cancer risk associated with Fas -1377 G/A polymorphism was revealed in Asians. Conclusions: The combined results suggest that Fas -1377 G/A polymorphism might modulate cancer susceptibility in an Asian-specific manner.

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0088748

DOI: 10.1371/journal.pone.0088748

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