Accelerated Development of Cervical Spine Instabilities in Rheumatoid Arthritis: A Prospective Minimum 5-Year Cohort Study

Takashi Yurube, Masatoshi Sumi, Kotaro Nishida, Hiroshi Miyamoto, Kozo Kohyama, Tsukasa Matsubara, Yasushi Miura, Hiroaki Hirata, Daisuke Sugiyama and Minoru Doita

PLOS ONE, 2014, vol. 9, issue 2, 1-10

Abstract: Objective: To clarify the incidence and predictive risk factors of cervical spine instabilities which may induce compression myelopathy in patients with rheumatoid arthritis (RA). Methods: Three types of cervical spine instability were radiographically categorized into “moderate” and “severe” based on atlantoaxial subluxation (AAS: atlantodental interval >3 mm versus ≥10 mm), vertical subluxation (VS: Ranawat value 5 years. The endpoint incidence of “severe” instabilities and predictors for “severe” instability were determined. Results: Patients with baseline “moderate” instability, including all sub-groups (AAS+ [VS− SAS−], VS+ [SAS− AAS±], and SAS+ [AAS± VS±]), developed “severe” instabilities more frequently (33.3% with AAS+, 75.0% with VS+, and 42.9% with SAS+) than those initially without instability (12.9%; p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0088970

DOI: 10.1371/journal.pone.0088970

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