How Often Should We Monitor for Reliable Detection of Atrial Fibrillation Recurrence? Efficiency Considerations and Implications for Study Design

Efstratios I Charitos, Paul D Ziegler, Ulrich Stierle, Derek R Robinson, Bernhard Graf, Hans-Hinrich Sievers and Thorsten Hanke

PLOS ONE, 2014, vol. 9, issue 2, 1-11

Abstract: Objective: Although atrial fibrillation (AF) recurrence is unpredictable in terms of onset and duration, current intermittent rhythm monitoring (IRM) diagnostic modalities are short-termed and discontinuous. The aim of the present study was to investigate the necessary IRM frequency required to reliably detect recurrence of various AF recurrence patterns. Methods: The rhythm histories of 647 patients (mean AF burden: 12±22% of monitored time; 687 patient-years) with implantable continuous monitoring devices were reconstructed and analyzed. With the use of computationally intensive simulation, we evaluated the necessary IRM frequency to reliably detect AF recurrence of various AF phenotypes using IRM of various durations. Results: The IRM frequency required for reliable AF detection depends on the amount and temporal aggregation of the AF recurrence (p 95% sensitivity) of AF recurrence required higher IRM frequencies (>12 24-hour; >6 7-day; >4 14-day; >3 30-day IRM per year; p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0089022

DOI: 10.1371/journal.pone.0089022

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