Decreased Seizure Threshold in an Eclampsia-Like Model Induced in Pregnant Rats with Lipopolysaccharide and Pentylenetetrazol Treatments

Qian Huang, Lei Liu, Bihui Hu, Xiaodan Di, Shaun Patrick Brennecke and Huishu Liu

PLOS ONE, 2014, vol. 9, issue 2, 1-8

Abstract: Objective: Eclampsia is a poorly understood but potentially fatal complication of pregnancy. Research to date on this disorder has been hampered by the lack of a suitable animal model. To correct this deficiency, this report describes the generation of a rat eclampsia-like model using pentylenetetrazol (PTZ) in a previously established rat preeclampsia model. Method: Rats were administered lipopolysaccharide (1.0 µg/kg) by tail vein injection on gestational day 14 to establish preeclampsia (PE). PE and control rats (non-pregnant, NP; normal-pregnant, P) were injected intraperitoneally (i.p.) with PTZ (40 mg/kg) to induce seizures. In separate experiments, MgSO4 (270 mg/kg IP) was injected in advance of PTZ into PE rats to observe its effect on PTZ-induced seizures. Results: PE conditions were verified in rats after LPS administration by significantly higher blood pressure (P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0089333

DOI: 10.1371/journal.pone.0089333

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