Evidence That HIV-1 CRF01_AE Is Associated with Low CD4+T Cell Count and CXCR4 Co-Receptor Usage in Recently Infected Young Men Who Have Sex with Men (MSM) in Shanghai, China

Xiaoshan Li, Yile Xue, Leiming Zhou, Yi Lin, Xiaolei Yu, Xuqin Wang, Xiaohong Zhen, Wei Zhang, Zhen Ning, Qing Yue, Jie Fu, Fangwei Shen, Jing Gai, Yuqing Xu, Jiawen Mao, Xianming Gao, Xiaopei Shen, Laiyi Kang, Guido Vanham, Hua Cheng, Ying Wang, Minghua Zhuang, Xun Zhuang, Qichao Pan and Ping Zhong

PLOS ONE, 2014, vol. 9, issue 2, 1-9

Abstract: Men who have sex with men (MSM) have recently accounted for an alarmingly increasing proportion of HIV-1 transmission in China. In order to investigate the immune status as a result of CRF01_AE infection and CXCR4 co-receptor usage in a young Shanghai-based HIV-1-infected MSM population in Shanghai, 364 HIV-1-infected MSM with average age of 22.7 years old, newly diagnosed between Jan 2009 and Jul 2013 were analyzed for CD4+T cell count, subtyping using phylogenetic analysis, and viral co-receptor tropism using Geno2pheno and webPSSM in combination. A total of 276 individuals were identified as recently infected. Subtype assignment were as follows: 176 (63.8%) CRF01_AE, 77 (27.9%) CRF07_BC, and 23 (8.3%) subtype B. Besides, 24 second-generation recombinant strains were identified. A lower CD4+T cell count at baseline survey was observed among CRF01_AE strain-infected individuals, compared to those who were infected with CRF07_BC (P 500 lower in CRF01_AE infection than CRF07_BC infection. It is worth noting that 32.4%–40.9% of CRF01_AE strain-infected individuals were predicted to carry CXCR4-tropic viruses whereas none of CRF07_BC and subtype B were found to be as CXCR4-tropic viruses (P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0089462

DOI: 10.1371/journal.pone.0089462

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