Dynamic Changes in Serum 25-Hydroxyvitamin D during Pregnancy and Lack of Effect on Thyroid Parameters

Yuhang Zhao, Wei Miao, Chenyang Li, Xiaohui Yu, Zhongyan Shan, Haixia Guan and Weiping Teng

PLOS ONE, 2014, vol. 9, issue 3, 1-7

Abstract: Background & Aims: To explore vitamin D status and its dynamic changes during pregnancy in women living in Northeast China. The association between 25-hydroxyvitamin D and serum calcium, phosphate and parathyroid hormone was studied. Because vitamin D deficiency or thyroid dysfunction/autoimmunity during pregnancy may lead to similar adverse events, the relationship between 25-hydroxyvitamin D and thyroid parameters was investigated. Methods: Serum samples of 50 women (aged 22 to 36 years) were selected retrospectively. The samples were collected at gestational 8 weeks ±3 days, 20 weeks ±3 days and 32 weeks ±3 days for measurement of 25-hydroxyvitamin D, calcium, phosphate, parathyroid hormone, and thyroid parameters. Results: The median 25-hydroxyvitamin D levels were 28.29, 39.23 and 40.03 nmol/L, respectively, from the first to the third trimester. The 25-hydroxyvitamin D concentration during the first trimester was significantly lower than the next two trimesters (p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0090161

DOI: 10.1371/journal.pone.0090161

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