Long Non-Coding RNA Expression Profiles in Hereditary Haemorrhagic Telangiectasia

Pernille M Tørring, Martin Jakob Larsen, Anette D Kjeldsen, Lilian Bomme Ousager, Qihua Tan and Klaus Brusgaard

PLOS ONE, 2014, vol. 9, issue 3, 1-12

Abstract: Hereditary Haemorrhagic Telangiectasia (HHT) is an autosomal dominantly inherited vascular disease characterized by the presence of mucocutaneous telangiectasia and arteriovenous malformations in visceral organs. HHT is predominantly caused by mutations in ENG and ACVRL1, which both belong to the TGF-β signalling pathway. The exact mechanism of how haploinsufficiency of ENG and ACVRL1 leads to HHT manifestations remains to be identified. As long non-coding RNAs (lncRNAs) are increasingly recognized as key regulators of gene expression and constitute a sizable fraction of the human transcriptome, we wanted to assess whether lncRNAs play a role in the molecular pathogenesis of HHT manifestations. By microarray technology, we profiled lncRNA transcripts from HHT nasal telangiectasial and non-telangiectasial tissue using a paired design. The microarray probes were annotated using the GENCODE v.16 dataset, identifying 4,810 probes mapping to 2,811 lncRNAs. Comparing HHT telangiectasial tissue with HHT non-telangiectasial tissue, we identified 42 lncRNAs that are differentially expressed (q

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0090272

DOI: 10.1371/journal.pone.0090272

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