Association between RANTES Gene Polymorphisms and Asthma: A Meta-Analysis

Dan Wen, Xin Du, Shao-Ping Nie, Jian-Zeng Dong and Chang-Sheng Ma

PLOS ONE, 2014, vol. 9, issue 6, 1-6

Abstract: Background: A few recent studies have suggested that regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms (−403 G/A, −28C/G) are associated with asthma. However, there still existed studies which did not confirm these correlations. Objective: The objective of this study was to evaluate the relationship of RANTES and asthma using a meta-analysis. Methods: Pubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers and pooled odds ratio (OR) with 95% confidence interval (CI) were calculated. Results: Eighteen studies were enrolled, including a total of 2558 cases and 2630 controls of −403 G/A, as well as 3311 cases and 4031 controls of −28C/G in this meta-analysis. The overall ORs and 95% CIs of −403 G/A were 1.19, 1.06–1.33 (P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0090460

DOI: 10.1371/journal.pone.0090460

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