Interobserver Reproducibility of Diffusion-Weighted MRI in Monitoring Tumor Response to Neoadjuvant Therapy in Esophageal Cancer

Robert M Kwee, Alexander K Dik, Meindert N Sosef, Ralph C M Berendsen, Sander Sassen, Guido Lammering, Ruud Clarijs, Liekele E Oostenbrug, Rachel L G M Blom and Roy F A Vliegen

PLOS ONE, 2014, vol. 9, issue 4, 1-11

Abstract: Objective: To investigate the reproducibility of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing tumor response early in the course of neoadjuvant chemoradiotherapy in patients with operable esophageal cancer. Methods: Eleven male patients (mean age 54.8 years) with newly diagnosed esophageal cancer underwent DW-MRI before and 10 days after start of chemoradiotherapy. Reproducibility of apparent diffusion coefficient (ADC) measurements by manual (freehand) and semi-automated volumetric methods was assessed. Results: Interobserver reproducibility for the assessment of mean tumor ADC by the manual measurement method was good, with an ICC of 0.69 (95% CI, 0.36 to 0.85; P = 0.001). Interobserver reproducibility for the assessment of mean tumor ADC by the semi-automated volumetric measurement method was very good, with an ICC of 0.96 (95% CI, 0.91 to 0.98; P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0092211

DOI: 10.1371/journal.pone.0092211

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