Statins for the Prevention of Stroke: A Meta-Analysis of Randomized Controlled Trials

Wen Wang and Bo Zhang

PLOS ONE, 2014, vol. 9, issue 3, 1-10

Abstract: Background: Stroke is a frequently encountered clinical event that has a detrimental impact on the quality of life. Evidence has increasingly shown that statins can substantially reduce the risk of coronary heart disease. However, it remains to be determined whether statins are definitively effective in preventing stroke. Methods: We systematically searched the PubMed, Embase, and Central databases for studies that compared the effects of statins and placebo in patients at high risk for stroke. The outcome measures were overall incidence of stroke, incidence of fatal stroke, and incidence of hemorrhagic stroke. Results: Eighteen randomized controlled trials satisfied all the inclusion criteria for the meta-analysis. The analysis revealed that statins reduced the overall incidence of stroke than placebo (odds ratio [OR]: 0.80; 95% confidence interval [CI]: 0.74–0.87; P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0092388

DOI: 10.1371/journal.pone.0092388

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