Baseline Plasma Fatty Acids Profile and Incident Cardiovascular Events in the SU.FOL.OM3 Trial: The Evidence Revisited

Léopold K Fezeu, François Laporte, Emmanuelle Kesse-Guyot, Valentina A Andreeva, Jacques Blacher, Serge Hercberg and Pilar Galan

PLOS ONE, 2014, vol. 9, issue 4, 1-11

Abstract: Objective: We aimed to investigate the association between baseline plasma fatty acids profile and the risk of future major cardiovascular events in patients with a history of ischaemic heart disease or ischemic stroke. Methods: Baseline plasma fatty acids as well as established cardiovascular risk factors were measured in 2,263 patients enrolled in the SUpplementation with FOLate, vitamins B-6 and B-12 and/or OMega-3 fatty acids randomized controlled trial. Incident major cardiovascular, cardiac and cerebrovascular events were ascertained during the 4.7 years of follow up. Hazard ratios were obtained from Cox proportional hazards models after adjustment for cardiovascular risk factors. Results: During the follow-up, 154, 379 and 84 patients had major cardiovascular, cardiac and cerebrovascular events respectively. Upon adjustment for gender, initial event, baseline age and BMI, the risk of developing a major cardiovascular event decreased significantly in successive quartiles of arachidonic acid (Ptrend

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0092548

DOI: 10.1371/journal.pone.0092548

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