Parity and Pancreatic Cancer Risk: A Dose-Response Meta-Analysis of Epidemiologic Studies

Hong-Bo Guan, Lang Wu, Qi-Jun Wu, Jingjing Zhu and Tingting Gong

PLOS ONE, 2014, vol. 9, issue 3, 1-7

Abstract: Background: Previous epidemiologic studies have reported inconsistent results between parity and pancreatic cancer (PC) risk. To our knowledge, a comprehensive and quantitative assessment of this association has not been conducted. Methods: Relevant published studies of parity and PC were identified using MEDLINE (PubMed) and Web of Science databases until November 2013. Two authors (H-BG and LW) independently assessed eligibility and extracted data. Eleven prospective and 11 case-control studies reported relative risk (RR) estimates and 95% confidence intervals (CIs) of PC associated with parity. Fixed- and random-effects models were used to estimate the summary RR depending on the heterogeneity of effects. Results: The summary RR for PC comparing the highest versus lowest parity was 0.86 (95% CI: 0.73–1.02; Q = 50.49, P

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0092738

DOI: 10.1371/journal.pone.0092738

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